Here are the next steps

STEP 3:

Receive your one-time BEQVEZ infusion

On the day of your infusion, you should plan to spend all day at the gene therapy infusion center.

This includes preparation time for your infusion. You may need to fill out some paperwork.

The process before, during, and after the infusion may vary across centers.

Your care team will give you a tailored follow-up plan to monitor your liver and factor IX (FIX) levels.

STEP 4:

After-treatment experience and monitoring

It will be important to see your care team for post-infusion monitoring routinely after the infusion.

You will have blood tests to assess your liver health and FIX activity levels.

In the clinical trial for BEQVEZ, some participants had raised liver enzyme levels and/or a decrease in FIX activity levels. Depending on their levels, these participants were prescribed corticosteroids.

Your care team will also remind you about:

• Limiting alcohol during the first year after the BEQVEZ infusion
• Not donating sperm and being abstinent or using a male condom for the first 6 months after your infusion

Talk to your doctor about enrolling in a registry to assess the long-term efficacy and safety of treatments for hemophilia.

After the infusion, when do you need to have scheduled follow-ups?

Post-infusion follow-ups, which include blood draws, are done 1 or 2 times a week in the first 4 months after receiving BEQVEZ and lessen over time.

Your care team may suggest that you visit the same lab for all your tests. This may help minimize any potential variability in results.

You can also speak to your doctor and nurse who may be able to help guide you to resources and tools after your BEQVEZ infusion.

Your care team may suggest that you visit the same lab for all your tests. This may help minimize any potential variability in results.

You can also speak to your doctor and nurse who may be able to help guide you to resources and tools after your BEQVEZ infusion.